Screening of Fifty Cunoniaceae Species from New Caledonia for Inhibitors of Xanthine Oxidase and Scavengers of Superoxide Anions

Bruno Fogliani (1) , Saliou Bouraïma-Madjèbi (2) , René Pineau (2) , Pierre Cabalion (3)

1 LBPVA - Laboratoire de Biologie et Physiologie Végétales Appliquées
2 UNC - Université de la Nouvelle-Calédonie
3 IRD [Nouvelle-Calédonie] - Institut de Recherche pour le Développement

Two-hundred-and-four extracts (101 ethyl acetate extracts and 103 methanol extracts) from 50 species of Cunoniaceae from New Caledonia were screened for antioxidant properties due to free radical scavenging and/or xanthine oxidase (XOD) inhibitory activity. Of the crude extracts, 95.1% were active at a concentration of 50 mg/ml. Fifteen (27.8%) extracts showed more than 50% activity at 10 mg/ml and were studied for XOD inhibition. All were active against XOD at 50 mg/ml but only 6 (40%) showed up to 60% inhibition. Ethyl acetate extracts from the bark of Weinmannia dichotoma Brongniart & Gris, Weinmannia monticola Däniker and Cunonia lin-earisepala (Guillaumin) Bernardi and from the roots of Codia incrassata Pampanini, as well as methanol extract from the bark of Pancheria brunhesii Pampanini, exhibited the highest activities (between 70% and 86% XOD inhibition at 50 mg/ml). In view of these preliminary results, New Caledonian Cunoniaceae species appears to be promising material for the isolation of bioactive compounds.

Mots clés: Cunoniaceae; ethyl acetate extract; free radical scavengers; methanol extract; New Caledonia; xanthine oxidase

Domaines: Sciences du Vivant [q-bio]

Bruno Fogliani, Saliou Bouraïma-Madjèbi, René Pineau, Pierre Cabalion. Screening of Fifty Cunoniaceae Species from New Caledonia for Inhibitors of Xanthine Oxidase and Scavengers of Superoxide Anions. Pharmaceutical biology, 2002, 40 (7), pp.526-533. ⟨10.1076/phbi.40.7.526.14690⟩. ⟨hal-02912882⟩